ATM monoclonal antibody, clone 9A2
产品名称: ATM monoclonal antibody, clone 9A2
英文名称: ATM monoclonal antibody, clone 9A2
产品编号: MAB0998
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinantATM.
- Immunogen:
- Recombinant His fusion protein corresponding to amino acids 2841-3056 of human ATM.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Isotype:
- IgG2b, kappa
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
Immunoprecipitation (1 ul)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Western Blot
- Immunoprecipitation
- Enzyme-linked Immunoabsorbent Assay
- Entrez GeneID:
- 472
- Gene Name:
- ATM
- Gene Alias:
- AT1,ATA,ATC,ATD,ATDC,ATE,DKFZp781A0353,MGC74674,TEL1,TELO1
- Gene Description:
- ataxia telangiectasia mutated
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- AT mutated,TEL1, telomere maintenance 1, homolog,ataxia telangiectasia mutated (includes complementation groups A, C and D),ataxia telangiectasia mutated protein,human phosphatidylinositol 3-kinase homolog,serine-protein kinase ATM
- Gene Pathway
- Related Disease
- Acute Disease
- Adenocarcinoma
- Ataxia Telangiectasia
- Ataxia telangiectasia
- Atherosclerosis
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Pancreatic Ductal
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Cocarcinogenesis
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis