MAP2K1 (phospho S217) Peptide
产品名称: MAP2K1 (phospho S217) Peptide
英文名称: MAP2K1 (phospho S217) Peptide
产品编号: P1470
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP2K1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S217 of human MAP2K1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3.
Xie S, Wang Q, Ruan Q, Liu T, Jhanwar-Uniyal M, Guan K, Dai W.Oncogene. 2004 May 6;23(21):3822-9.
- 2.
- MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells.
Rhee SH, Keates AC, Moyer MP, Pothoulakis C.J Biol Chem. 2004 Jun 11;279(24):25179-88. Epub 2004 Apr 6.
- 3.
- Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts.
Takahashi-Yanaga F, Shiraishi F, Hirata M, Miwa Y, Morimoto S, Sasaguri T.Biochem Biophys Res Commun. 2004 Apr 2;316(2):411-5.
- Applications
- Western Blot (Cell lysate)
- MAP2K1 (phospho S217) polyclonal antibody (Cat # PAB0506). Western blot analysis of MAP2K1 expression in HeLa.
- Protocol Download
- Entrez GeneID:
- 5604
- Protein Accession#:
- NP_002746;Q02750
- Gene Name:
- MAP2K1
- Gene Alias:
- MAPKK1,MEK1,MKK1,PRKMK1
- Gene Description:
- mitogen-activated protein kinase kinase 1
- Omim ID:
- 176872
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq
- Other Designations:
- protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Dorso-ventral axis formation
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prion diseases
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Thyroid cancer
- Toll-like receptor signaling pathway
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cognition Disorders
- Developmental Disabilities
- Ectodermal Dysplasia
- Genetic Predisposition to Disease
- Glioma
- Heart Defects, Congenital
- LEOPARD Syndrome
- Lung Neoplasms
- Mental Retardation
- Noonan Syndrome
- Pancreatic Neoplasms
- Skin Abnormalities
- Syndrome