AIFM1 polyclonal antibody
产品名称： AIFM1 polyclonal antibody
英文名称： AIFM1 polyclonal antibody
产品编号： PAB9937
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AIFM1.
- Immunogen:
- A synthetic peptide corresponding to internal region of human AIFM1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.25-1 ug/mL)
Immunohistochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis.
Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N, Prevost MC, Leber B, Andrews D, Penninger J, Kroemer G.FASEB J. 2000 Apr;14(5):729-39.
- 2.
- Condensed matter in cell death.
Zamzami N, Kroemer G.Nature. 1999 Sep 9;401(6749):127-8.
- 3.
- Molecular characterization of mitochondrial apoptosis-inducing factor.
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G.Nature. 1999 Feb 4;397(6718):441-6.
- Applications
- Western Blot
- Western blot analysis of AIFM1 in (A) K-562 cell lysate, (B) rat heart, and (C) mouse heart tissue lysates with AIFM1 polyclonal antibody (Cat # PAB9937) at 1 ug/mL .
- Entrez GeneID:
- 9131
- Protein Accession#:
- O95831
- Gene Name:
- AIFM1
- Gene Alias:
- AIF,MGC111425,PDCD8
- Gene Description:
- apoptosis-inducing factor, mitochondrion-associated, 1
- Omim ID:
- 300169
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000024007,OTTHUMP00000024008,OTTHUMP00000024009,programmed cell death 8,programmed cell death 8 (apoptosis-inducing factor),striatal apoptosis-inducing factor
- Gene Pathway