DMPK (C-term) Peptide
产品名称： DMPK (C-term) Peptide
英文名称： DMPK (C-term) Peptide
产品编号： P2124
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DMPK.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DMPK.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Different expression of the myotonin protein kinase gene in discrete areas of human brain.
Gennarelli M, Lucarelli M, Zelano G, Pizzuti A, Novelli G, Dallapiccola B.Biochem Biophys Res Commun. 1995 Nov 13;216(2):489-94.
- 2.
- Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells.
Sasagawa N, Sorimachi H, Maruyama K, Arahata K, Ishiura S, Suzuki K.FEBS Lett. 1994 Aug 29;351(1):22-6.
- 3.
- Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene.
Mahadevan MS, Amemiya C, Jansen G, Sabourin L, Baird S, Neville CE, Wormskamp N, Segers B, Batzer M, Lamerdin J, et al..Hum Mol Genet. 1993 Mar;2(3):299-304.
- Entrez GeneID:
- 1760
- Protein Accession#:
- Q09013
- Gene Name:
- DMPK
- Gene Alias:
- DM,DM1,DM1PK,DMK,MDPK,MT-PK
- Gene Description:
- dystrophia myotonica-protein kinase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
- Other Designations:
- DM protein kinase,dystrophia myotonica 1,myotonic dystrophy associated protein kinase,myotonic dystrophy protein kinase,myotonin protein kinase A,thymopoietin homolog
- Related Disease
- Arrhythmia
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Cataract
- Chromosome Disorders
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Fragile X Syndrome
- Fragile X syndrome
- Friedreich Ataxia
- Friedreich's ataxia
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- Muscular Atrophy, Spinal
- Myotonic Dystrophy
- Myotonic dystrophy