NR1I2 purified MaxPab mouse polyclonal antibody (B01P)
产品名称： NR1I2 purified MaxPab mouse polyclonal antibody (B01P)
英文名称： NR1I2 purified MaxPab mouse polyclonal antibody (B01P)
产品编号： H00008856-B01P
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human NR1I2 protein.
- Immunogen:
- NR1I2 (NP_003880.3, 1 a.a. ~ 434 a.a) full-length human protein.
- Sequence:
- MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
- Host:
- Mouse
- Reactivity:
- Human, Rat
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Tissue lysate)
- NR1I2 MaxPab polyclonal antibody. Western Blot analysis of NR1I2 expression in rat liver.
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of NR1I2 expression in transfected 293T cell line (H00008856-T01) by NR1I2 MaxPab polyclonal antibody.
Lane 1: NR1I2 transfected lysate(47.74 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Immunofluorescence
enlarge this image- Immunofluorescence of purified MaxPab antibody to NR1I2 on HepG2 cell. [antibody concentration 10 ug/ml]
- Protocol Download
- Entrez GeneID:
- 8856
- GeneBank Accession#:
- NM_003889.2
- Protein Accession#:
- NP_003880.3
- Gene Name:
- NR1I2
- Gene Alias:
- BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR
- Gene Description:
- nuclear receptor subfamily 1, group I, member 2
- Omim ID:
- 603065
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq
- Other Designations:
- orphan nuclear receptor PXR,steroid and xenobiotic receptor
- Related Disease
- Anemia
- Asthma
- Asthma
- Birth Weight
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Cholangitis, Sclerosing
- Cholestasis, Intrahepatic
- Colitis, Ulcerative
- Colon cancer
- Colonic Neoplasms
- Coronary Artery Disease
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- Drug-Induced Liver Injury