Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Rat Platelet-derived Growth Factor-BB
                
(Rat PDGF-BB)
                
                

                
91603ES10
                
                

                
10 μg
                
                

                
1855.00
                
            
            

                

                
91603ES60
                
                

                
100 μg
                
                

                
12045.00
                
            
            

                

                
91603ES76
                
                

                
500 μg
                
                

                
26545.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. The PDGF signaling system contributes to and vascular remodeling. Growth factors such as PDGF exert potent effects on wound healing including the regeneration of tooth-supporting structures. Some research reports findings in this chronic myocardial infarction model were that bFGF, PDGF-BB and their combination all had a more pronounced angiogenic effect on the arteriolar than the capillary level. bFGF stimulated both capillary and arteriolar growth while PDGF-BB preferentially stimulated arterioles.
    
 
    
Product Properties
    
 
    

    

            

                

                    

                        

                            
                        
                    
                
            
        





























        

            

                

                
Synonyms
                
                

                
Becaplermin, ODGF, PDGF-2, PDGFBB, PDGF-BB
                
            
            

                

                
Accession
                
                

                
Q05028
                
            
            

                

                
GeneID
                
                

                
24628
                
            
            

                

                
Source
                
                

                
E.coli-derived rat PDGF-BB protein, Ser74-Thr182.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 24.4 kDa.
                
            
            

                

                
AA Sequence
                
                

                
SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPVFKKATVT LEDHLACKCE TVVTPRPVT
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                

                
Physical Appearance
                
                

                
Sterile Filtered White lyophilized (freeze-dried) powder.