LRP1 (phospho S452) polyclonal antibody
产品名称： LRP1 (phospho S452) polyclonal antibody
英文名称： LRP1 (phospho S452) polyclonal antibody
产品编号： PAB4911
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of LRP1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S452 of human LRP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Immunohistochemistry (1:50-100)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.
Cam JA, Zerbinatti CV, Li Y, Bu G.J Biol Chem. 2005 Apr 15;280(15):15464-70. Epub 2005 Feb 10.
- 2.
- Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner.
Yu G, Rux AH, Ma P, Bdeir K, Sachais BS.Blood. 2005 May 1;105(9):3545-51. Epub 2004 Dec 9.
- 3.
- Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone.
Niemeier A, Kassem M, Toedter K, Wendt D, Ruether W, Beisiegel U, Heeren J.J Bone Miner Res. 2005 Feb;20(2):283-93. Epub 2004 Nov 1.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with LRP1 (phospho S452) polyclonal antibody (Cat # PAB4911) which was peroxidase-conjugated to the secondary antibody followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 4035
- Protein Accession#:
- NP_002323;Q07954
- Gene Name:
- LRP1
- Gene Alias:
- A2MR,APOER,APR,CD91,FLJ16451,IGFBP3R,LRP,MGC88725,TGFBR5
- Gene Description:
- low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
- Omim ID:
- 107770
- Gene Ontology:
- Hyperlink
- Other Designations:
- TbetaR-V/LRP-1/IGFBP-3 receptor,alpha-2-macroglobulin receptor,low density lipoprotein-related protein 1,type V tgf-beta receptor
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Amnesia
- Atherosclerosis
- Atherosclerosis
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Carcinoma, Endometrioid
- Cardiovascular Diseases
- Cerebral Amyloid Angiopathy
- Cognition Disorders
- Coronary Artery Disease
- Coronary Disease
- Cystadenocarcinoma, Serous
- Dementia
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Progression