IL12B (Human) ELISA Kit
产品名称： IL12B (Human) ELISA Kit
英文名称： IL12B (Human) ELISA Kit
产品编号： KA0374
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
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- Specification
- Product Description:
- IL12B (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human IL12B.
- Calibration Range:
- 31.2 to 2000 pg/mL
- Limit of Detection:
- 2 pg/mL
- Reactivity:
- Human
- Storage Instruction:
- Store the kit at 4°C for 4 months. For long term storage, please store at -20°C for 8 months.
- Quality Control Testing:
- Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
- Protocol:
Protocol Download
- MSDS:
- Download
- Suitable Sample:
- Body Fluid, Cell Culture Supernatant, Plasma, Serum, Tissue Lysate
- Sample Volume:
- 100 uL
- Label:
- Biotin-conjugate
- Detection Method:
- Colorimetric
- Regulation Status:
- For research use only (RUO)
- Publication Reference
- 1.
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD.Nature. 2003 Feb 13;421(6924):744-8.
- 2.
- Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.
Becher B, Durell BG, Noelle RJ.J Clin Invest. 2002 Aug;110(4):493-7.
- 3.
- Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
Sieburth D, Jabs EW, Warrington JA, Li X, Lasota J, LaForgia S, Kelleher K, Huebner K, Wasmuth JJ, Wolf SF.Genomics. 1992 Sep;14(1):59-62.
- Application Image
- Quantification
- Entrez GeneID:
- 3593
- Gene Name:
- IL12B
- Gene Alias:
- CLMF,CLMF2,IL-12B,NKSF,NKSF2
- Gene Description:
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq
- Other Designations:
- IL12, subunit p40,OTTHUMP00000160820,cytotoxic lymphocyte maturation factor 2, p40,interleukin 12, p40,interleukin 12B,interleukin-12 beta chain,natural killer cell stimulatory factor, 40 kD subunit,natural killer cell stimulatory factor-2
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