CDKN1B (Human) Recombinant Protein (Q02)
产品名称: CDKN1B (Human) Recombinant Protein (Q02)
英文名称: CDKN1B (Human) Recombinant Protein (Q02)
产品编号: H00001027-Q02
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human CDKN1B partial ORF ( ENSP00000228872, 100 a.a. - 198 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- KVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
- Theoretical MW (kDa):
- 36.63
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 1027
- GeneBank Accession#:
- NM_004064
- Protein Accession#:
- ENSP00000228872
- Gene Name:
- CDKN1B
- Gene Alias:
- CDKN4,KIP1,MEN1B,MEN4,P27KIP1
- Gene Description:
- cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
- Other Designations:
- cyclin-dependent kinase inhibitor 1B
- Related Disease
- Acromegaly
- Adenocarcinoma
- Adenocarcinoma, Follicular
- Alzheimer Disease
- Alzheimer disease
- Ataxia telangiectasia
- Atherosclerosis
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Papillary, Follicular
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Cognition
- Colon cancer
- Colorectal Neoplasms