FCGR3A/FCGR3B monoclonal antibody, clone GRM1 (SPRD)
产品名称： FCGR3A/FCGR3B monoclonal antibody, clone GRM1 (SPRD)
英文名称： FCGR3A/FCGR3B monoclonal antibody, clone GRM1 (SPRD)
产品编号： MAB6053
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native FCGR3A/FCGR3B.
- Immunogen:
- Native purified from human prolymphocytic leukemia cells.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- Specificity human CD16/FcgammaRIII
- Form:
- Liquid
- Conjugation:
- SPRD
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS (sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (10 ul/106 cells)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- FcR gamma chain deletion results in pleiotrophic effector cell defects.
Takai T, Li M, Sylvestre D, Clynes R, Ravetch JV.Cell. 1994 Feb 11;76(3):519-29.
- 2.
- Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
Ravetch JV, Perussia B.J Exp Med. 1989 Aug 1;170(2):481-97.
- Application Image
- Western Blot
- Immunohistochemistry (Frozen sections)
- Flow Cytometry
- Entrez GeneID:
- 2214
- Gene Name:
- FCGR3A
- Gene Alias:
- CD16,CD16A,FCG3,FCGR3,FCGRIII,FCR-10,FCRIII,FCRIIIA,IGFR3
- Gene Description:
- Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- Fc fragment of IgG, low affinity III, receptor for (CD16),Fc fragment of IgG, low affinity IIIa, receptor for (CD16),Fc gamma receptor III-A,Fc-gamma RIII-alpha,Fc-gamma RIIIa,Fc-gamma receptor III-2 (CD 16),Fc-gamma receptor IIIb (CD16),FcgammaRIIIA,OTTH
- Entrez GeneID:
- 2215
- Gene Name:
- FCGR3B
- Gene Alias:
- CD16,CD16b,FCG3,FCGR3
- Gene Description:
- Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
- Omim ID:
- 610665
- Gene Ontology:
- Hyperlink
- Other Designations:
- Fc fragment of IgG, low affinity IIIb, receptor for (CD16),Fc-gamma receptor IIIb (CD 16),low affinity immunoglobulin gamma Fc region receptor III-B
- Interactome
