PRKAR2B polyclonal antibody (A01)
产品名称： PRKAR2B polyclonal antibody (A01)
英文名称： PRKAR2B polyclonal antibody (A01)
产品编号： H00005577-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant PRKAR2B.
- Immunogen:
- PRKAR2B (NP_002727, 304 a.a. ~ 413 a.a) partial recombinant protein with GST tag.
- Sequence:
- IAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
- MSDS:
Download
- Application Image
- Western Blot (Recombinant protein)
- ELISA
- Entrez GeneID:
- 5577
- GeneBank Accession#:
- NM_002736
- Protein Accession#:
- NP_002727
- Gene Name:
- PRKAR2B
- Gene Alias:
- PRKAR2,RII-BETA
- Gene Description:
- protein kinase, cAMP-dependent, regulatory, type II, beta
- Omim ID:
- 176912
- Gene Ontology:
- Hyperlink
- Gene Summary:
- cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq
- Other Designations:
- H_RG363E19.2,WUGSC:H_RG363E19.2,cAMP-dependent protein kinase type II-beta regulatory chain,cAMP-dependent protein kinase, regulatory subunit beta 2
- Gene Pathway